Objective. To study the clinical and laboratory features of the course of salmonellosis in adults.

Results. The results of the study showed that the predominant causative agent of salmonellosis in patients older than 45 years is Salmonella enteritidis (more than 75%), with an afebrile course of the disease observed in 30% of cases. Identification of the most appropriate inflammatory response markers for use in an infectious disease inpatient setting, such as C-reactive protein levels and fecal calprotectin assessed dynamically, is becoming increasingly relevant due to the detection of a group of patients with an ongoing inflammatory process. This facilitates the identification of patients who require early rehabilitation.

Conclusion. Determination of fecal calprotectin and CRR levels makes a significant contribution to distinguishing patients with a tendency toward a prolonged inflammatory process in the gastrointestinal tract in salmonellosis.

Salmonellosis, C-reactive protein, procalcitonin

Zaplutanov V.A., Romantsov M.G., Tikhonova E.O., Almyasheva R.Z., Lyapina E.P., Pavelkina V.F., Shuldyakov A.A. Features of the course of acute intestinal infections with an assessment of the effectiveness of pathogenetic therapy. Antibiotics and Chemotherapy. 2012;57(9-10):17-24. https://cyberleninka.ru/article/n/osobennosti-techeniya-ostryh-kishechnyh-infektsiy-s-otsenkoy-effektivnosti-patogeneticheskoy-terapii

Galán-Relaño Á, Valero Díaz A, Huerta Lorenzo B, Gómez-Gascón L, Mena Rodríguez MªÁ, Carrasco Jiménez E, Pérez Rodríguez F, Astorga Márquez RJ. Salmonella and Salmonellosis: An Update on Public Health Implications and Control Strategies. Animals (Basel). 2023 Nov 27;13(23):3666. doi: 10.3390/ani13233666. PMID: 38067017; PMCID: PMC10705591.

Klimovitskaya E. G., Eshmolov S. N., Sitnikov I. G. Clinical, epidemiological and laboratory features of salmonellosis in children at the present stage. Childhood infections. 2019; 18(4):49-52 https://doi.org/10.22627/2072-8107-2019-18-4-49-52

Bogutsky M. I. Salmonella infection // Journal of the Russian State Medical University. 2011. № 1 (33). https://cyberleninka.ru/article/n/salmonelleznaya-infektsiya

Tikhonova E.P., Kuzmina T.Yu., Minoranskaya N.S., Lipnyagova S.V., Kalinina Yu.S., Levitsky S.V., Gulik V.V. Salmonellosis in adults: clinical and epidemiological features, optimization of therapy // Infectious diseases: news, opinions, education. 2020;9(4):98-102. https://doi.org/10.33029/2305-3496-2020-9-4-98-102

Bogutsky M. I. Salmonella infection // Journal of the Russian State Medical University. 2011;1(33):26-32 https://cyberleninka.ru/article/n/salmonelleznaya-infektsiya

Akhmedova M.D., Imamova I.A., Boyturaev Sh.I., Turobov B.T., Saidova S.G.

Features of the course and therapy of acute infectious diarrhea accompanying hemocolitis syndrome. Of the South-Kazakhstan medicina academy Republican scientific journalр. - № 4 (84), 2018, Volume 3, Р. 115-116 https://lib.ukma.kz/wp-content/uploads/2021/02/2018-04-5.pdf#page=116

Tuychiev L.N., Tadjiev B.M., Tadjieva N.U., Bektemirov A.A., Kasimov O.Sh., Karimova N.N., Anvarov J.A., Yusupov A.P. Technology for Producing Hyperimmune Agglutinating Sera against Salmonella using Various Immunization Schemes and Studying the Biochemical and Immunological Parameters of the Sera. Epidemiology and Vaccinal Prevention. 2025;25(4):77-85. (In Russ.) https://doi.org/10.31631/2073-3046-2025-24-4-77-85